Shab K+channel slow inactivation
نویسندگان
چکیده
منابع مشابه
It's spring-time for slow inactivation
457 C o m m e n t a r y Some voltage-activated ion channels have evolved ways of terminating or limiting ionic flux even when a depo-larized membrane potential would keep them open. When Hodgkin and Huxley observed the time-dependent decay of Na + permeability in the squid giant axon, they termed it " inactivation " (Hodgkin and Huxley, 1952). This process, which takes place in the millisecond ...
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Voltage-gated Na+ channels exhibit two forms of inactivation, one form (fast inactivation) takes effect on the order of milliseconds and the other (slow inactivation) on the order of seconds to minutes. While previous studies have suggested that fast and slow inactivation are structurally independent gating processes, little is known about the relationship between the two. In this study, we pro...
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Mutations in the voltage-gated sodium channel Nav1.7 are linked to inherited pain syndromes such as erythromelalgia (IEM) and paroxysmal extreme pain disorder (PEPD). PEPD mutations impair Nav1.7 fast inactivation and increase persistent currents. PEPD mutations also increase resurgent currents, which involve the voltage-dependent release of an open channel blocker. In contrast, IEM mutations, ...
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Syntaxin, a membrane protein vital in triggering vesicle fusion, interacts with voltage-gated N- and P/Q-type Ca(2+) channels. This biochemical association is proposed to colocalize Ca(2+) channels and presynaptic release sites, thus supporting rapid and efficient initiation of neurotransmitter release. The syntaxin channel interaction may also support a novel signaling function, to modulate Ca...
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ژورنال
عنوان ژورنال: Channels
سال: 2013
ISSN: 1933-6950,1933-6969
DOI: 10.4161/chan.23569